Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases formatIsbn:Softcover - 9789400798953 CHAPTER ONE: INTRODUCTION1

CHAPTER ONE: INTRODUCTION1

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Furthermore it will be represented how this process can be embedded in an integral approach

Wirtschaftsgütergesamtheiten

Non-fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases formatIsbn:Softcover - 9789400798953 CHAPTER ONE: INTRODUCTION1Amyloid forming proteins are implicated in over 30 human diseases. The proteins involved in each disease have unrelated sequences and dissimilar native structures, but they all undergo conformational alterations to form fibrillar polymers. The fibrillar assemblies accumulate progressively into disease specific lesions in vivo. Substantial evidence suggests these lesions are the end state of aberrant protein folding whereas the actual disease causing